Application of Ion Cyclotron Resonance to the Study of Inelastic Excitation by Low-Energy Electrons

The geometry of the resonance cell employed for ion cyclotron resonance spectroscopy (1-3) is ideally suited for studying inelastic excitation by low-energy electrons. It has been shown that the electron beam traverses a parabolic potential well between the trapping electrodes, the depth of which is approximately half the applied trapping voltage (3,4). Low-energy electrons generated by impact excitation of an atomic or molecular energy level can be trapped in the resonance cell if their final translational energy is insufficient to escape the preset depth of the potential well. These electrons can be drifted from the source of the resonance region by applying the usual static drift field E normal to the primary magnetic field H (4). The electron drift velocity in this crossed field geometry, given by cE/H, is independent of both charge and mass. For typical values of E and H the drift velocity is in the range of 10^1-10^3 cm/sec. In the lower range of accessible drift velocities, the residence time of electrons in the resonance cell approaches 0.1 sec

The Near-Infrared Extinction Law in Regions of High Av

We present a spectroscopic study of the shape of the dust-extinction law between 1.0 and 2.2um towards a set of nine ultracompact HII regions with Av > 15 mag. We find some evidence that the reddening curve may tend to flatten at higher extinctions, but just over half of the sample has extinction consistent with or close to the average for the interstellar medium. There is no evidence of extinction curves significantly steeper than the standard law, even where water ice is present. Comparing the results to the predictions of a simple extinction model, we suggest that a standard extinction law implies a robust upper limit to the grain-size distribution at around 0.1 - 0.3um. Flatter curves are most likely due to changes in this upper limit, although the effects of flattening due to unresolved clumpy extinction cannot be ruled out.Comment: 9 pages, 7 figure

The interaction of ions with nonpolar neutrals: The collision broadening of ion cyclotron resonance lines of ions in hydrogen and methane

The motion of ions in an ion cyclotron resonance cell is considered, and measurements of ion cyclotron resonance linewidths are described. The connection between cyclotron resonance linewidths and kinetic parameters is developed. Mobilities and collision frequencies of CH5 + , C2H5 + , C3H7 + , C4H9 + , and Na + in methane and H + , H3 + , H30 + , CH5 + , C2H5 + , C3H7 + , and Na + in hydrogen are determined from the linewidth measurements. Resulting mobilities of H + , H3 + , and Na + in H2 are found to agree well with drift tube measurements, in contrast to previous cyclotron resonance linewidth determinations. The mobilities are interpreted in terms of three model ion molecule interaction potentials. The mobilities are found to be in general consistent with both a three term 12–6–4 potential and an acentric potential but not with the simple polarization potential. Potential parameters consistent with binding energies from the literature and the present mobility measurements are reported for H3 + –H2, CH5 + –CH4, and C2H5 + –CH4

Helium and Hydrogen Line Ratios and The Stellar Content of Compact HII Regions

We present observations and models of the behaviour of the HI and HeI lines between 1.6 and 2.2um in a small sample of compact HII regions. As in our previous papers on planetary nebulae, we find that the `pure' 1.7007um 4^3D-3^3P and 2.16475um 7^(3,1)G-4^(3,1)F HeI recombination lines behave approximately as expected as the effective temperature of the central exciting star(s) increases. However, the 2.058um 2^1P-2^1S HeI line does not behave as the model predicts, or as seen in planetary nebulae. Both models and planetary nebulae showed a decrease in the HeI 2^1P-2^1S/HI Br gamma ratio above an effective temperature of 40000K. The compact HII regions do not show any such decrease. The problem with this line ratio is probably due to the fact that the photoionisation model does not account correctly for the high densities seen in these HII regions, and that we are therefore seeing more collisional excitation of the 2^1P level than the model predicts. It may also reflect some deeper problem in the assumed model stellar atmospheres. In any event, although the normal HeI recombination lines can be used to place constraints on the temperature of the hottest star present, the HeI 2^1P-2^1S/HI Br gamma ratio should not be used for this purpose in either Galactic HII regions or in starburst galaxies, and conclusions from previous work using this ratio should be regarded with extreme caution. We also show that the combination of the near infrared `pure' recombination line ratios with mid-infrared forbidden line data provides a good discriminant of the form of the far ultraviolet spectral energy distribution of the exciting star(s). From this we conclude that CoStar models are a poor match to the available data for our sources, though the more recent WM-basic models are a better fit.Comment: Accepted for publication in MNRA

Sick of the sick role: narratives of what ‘recovery’ means to people with chronic fatigue syndrome/myalgic encephalomyelitis

Little is known about what recovery means to those with chronic fatigue syndrome/myalgic encephalomyelitis, a poorly understood, disabling chronic health condition. To explore this issue, semi-structured interviews were conducted with patients reporting improvement (n=9) and deterioration (n=10) after a guided self-help intervention, and analysed via “constant comparison”. The meaning of recovery differed between participants - expectations for improvement and deployment of the sick role (and associated stigma) were key influences. Whilst some saw recovery as complete freedom from symptoms, many defined it as freedom from the ‘sick role’, with functionality prioritized. Others redefined recovery, reluctant to return to the lifestyle that may have contributed to their illness, or rejected the concept as unhelpful. Recovery is not always about eliminating all symptoms. Rather, it is a nexus between the reality of limited opportunities for full recovery, yet a strong desire to leave the illness behind and regain a sense of ‘normality’

Amine reactivity with charged sulfuric acid clusters

The distribution of charged species produced by electrospray of an ammonium sulfate solution in both positive and negative polarities is examined using Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS). Positively-charged ammonium bisulfate cluster composition differs significantly from negatively-charged cluster composition. For positively-charged clusters all sulfuric acid is neutralized to bisulfate, whereas for negatively-charged clusters the degree of sulfuric acid neutralization is cluster size-dependent. With increasing cluster size (and, therefore, a decreasing role of charge), both positively- and negatively-charged cluster compositions converge toward ammonium bisulfate. The reactivity of negatively-charged sulfuric acid-ammonia clusters with dimethylamine and ammonia is also investigated by FTICR-MS. Two series of negatively-charged clusters are investigated: [(HSO<sub>4</sub>)(H<sub>2</sub>SO<sub>4</sub>)<sub>x</sub>]<sup>−</sup> and [(NH<sub>4</sub>)<sub>x</sub>(HSO<sub>4</sub>)<sub>x+1</sub>(H<sub>2</sub>SO<sub>4</sub>)<sub>3</sub>]<sup>−</sup>. Dimethylamine substitution for ammonia in [(NH<sub>4</sub>)<sub> x</sub>(HSO<sub>4</sub>)<sub> x+1</sub>(H<sub>2</sub>SO<sub>4</sub>)<sub>3</sub>]<sup>−</sup> clusters is nearly collision-limited, and subsequent addition of dimethylamine to neutralize H<sub>2</sub>SO<sub>4</sub> to bisulfate is within one order of magnitude of the substitution rate. Dimethylamine addition to [(HSO<sub>4</sub>) (H<sub>2</sub>SO<sub>4</sub>)<sub> x</sub>]<sup>−</sup> clusters is either not observed or very slow. The results of this study indicate that amine chemistry will be evident and important only in large ambient negative ions (><i>m/z</i> 400), whereas amine chemistry may be evident in small ambient positive ions. Addition of ammonia to unneutralized clusters occurs at a rate that is ~2–3 orders of magnitude slower than incorporation of dimethylamine either by substitution or addition. Therefore, in locations where amine levels are within a few orders of magnitude of ammonia levels, amine chemistry may compete favorably with ammonia chemistry

Reducing weight and increasing physical activity in people at high risk of cardiovascular disease: a randomised controlled trial comparing the effectiveness of enhanced motivational interviewing intervention with usual care.

OBJECTIVE: The epidemic of obesity is contributing to the increasing prevalence of people at high risk of cardiovascular disease (CVD), negating the medical advances in reducing CVD mortality. We compared the clinical and cost-effectiveness of an intensive lifestyle intervention consisting of enhanced motivational interviewing in reducing weight and increasing physical activity for patients at high risk of CVD. METHODS: A three-arm, single-blind, parallel-group randomised controlled trial was conducted in consenting primary care centres in south London. We recruited patients aged 40-74 years with a QRisk2 score ≥20.0%, which indicates the probability of having a CVD event in the next 10 years. The intervention was enhanced motivational interviewing which included additional behaviour change techniques and was delivered by health trainers in 10 sessions over 1 year, in either group (n=697) or individual (n=523) format. The third arm received usual care (UC; n=522). The primary outcomes were physical activity (mean steps/day) and weight (kg). Secondary outcomes were changes in low-density lipoprotein cholesterol and CVD risk score. We estimated the relative cost-effectiveness of each intervention. RESULTS: At 24 months, the group and individual interventions were not more effective than UC in increasing physical activity (mean difference=70.05 steps, 95% CI -288.00 to 147.90 and mean difference=7.24 steps, 95% CI -224.01 to 238.50, respectively), reducing weight (mean difference=-0.03 kg, 95% CI -0.49 to 0.44 and mean difference=-0.42 kg, 95% CI -0.93 to 0.09, respectively) or improving any secondary outcomes. The group and individual interventions were not cost-effective at conventional thresholds. CONCLUSIONS: Enhancing motivational interviewing with additional behaviour change techniques was not effective in reducing weight or increasing physical activity in those at high CVD risk

Enhanced motivational interviewing for reducing weight and increasing physical activity in adults with high cardiovascular risk: the MOVE IT three-arm RCT.

BACKGROUND: Motivational interviewing (MI) enhanced with behaviour change techniques (BCTs) and deployed by health trainers targeting multiple risk factors for cardiovascular disease (CVD) may be more effective than interventions targeting a single risk factor. OBJECTIVES: The clinical effectiveness and cost-effectiveness of an enhanced lifestyle motivational interviewing intervention for patients at high risk of CVD in group settings versus individual settings and usual care (UC) in reducing weight and increasing physical activity (PA) were tested. DESIGN: This was a three-arm, single-blind, parallel randomised controlled trial. SETTING: A total of 135 general practices across all 12 South London Clinical Commissioning Groups were recruited. PARTICIPANTS: A total of 1742 participants aged 40-74 years with a ≥ 20.0% risk of a CVD event in the following 10 years were randomised. INTERVENTIONS: The intervention was designed to integrate MI and cognitive-behavioural therapy (CBT), delivered by trained healthy lifestyle facilitators in 10 sessions over 1 year, in group or individual format. The control group received UC. RANDOMISATION: Simple randomisation was used with computer-generated randomisation blocks. In each block, 10 participants were randomised to the group, individual or UC arm in a 4 : 3 : 3 ratio. Researchers were blind to the allocation. MAIN OUTCOME MEASURES: The primary outcomes are change in weight (kg) from baseline and change in PA (average number of steps per day over 1 week) from baseline at the 24-month follow-up, with an interim follow-up at 12 months. An economic evaluation estimates the relative cost-effectiveness of each intervention. Secondary outcomes include changes in low-density lipoprotein cholesterol and CVD risk score. RESULTS: The mean age of participants was 69.75 years (standard deviation 4.11 years), 85.5% were male and 89.4% were white. At the 24-month follow-up, the group and individual intervention arms were not more effective than UC in increasing PA [mean 70.05 steps, 95% confidence interval (CI) -288 to 147.9 steps, and mean 7.24 steps, 95% CI -224.01 to 238.5 steps, respectively] or in reducing weight (mean -0.03 kg, 95% CI -0.49 to 0.44 kg, and mean -0.42 kg, 95% CI -0.93 to 0.09 kg, respectively). At the 12-month follow-up, the group and individual intervention arms were not more effective than UC in increasing PA (mean 131.1 steps, 95% CI -85.28 to 347.48 steps, and mean 210.22 steps, 95% CI -19.46 to 439.91 steps, respectively), but there were reductions in weight for the group and individual intervention arms compared with UC (mean -0.52 kg, 95% CI -0.90 to -0.13 kg, and mean -0.55 kg, 95% CI -0.95 to -0.14 kg, respectively). The group intervention arm was not more effective than the individual intervention arm in improving outcomes at either follow-up point. The group and individual interventions were not cost-effective. CONCLUSIONS: Enhanced MI, in group or individual formats, targeted at members of the general population with high CVD risk is not effective in reducing weight or increasing PA compared with UC. Future work should focus on ensuring objective evidence of high competency in BCTs, identifying those with modifiable factors for CVD risk and improving engagement of patients and primary care. TRIAL REGISTRATION: Current Controlled Trials ISRCTN84864870. FUNDING: This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 23, No. 69. See the NIHR Journals Library website for further project information. This research was part-funded by the NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London

A novel axial flux permanent magnet generator for wind turbines

This paper presents the development of a framework used to optimize and experimentally validate a novel axial flux direct-drive (DD) permanent magnet generator (PMG) for the offshore wind turbine market. This technology aims to offer significant levelized cost of energy (LCoE) reductions via capital expenditure and operating expense (CAPEX and OPEX) savings – a key objective for the offshore industry. The DD-PMG technology uses ferrite magnets to create the magnetic field, which is a significant source of cost reduction. The use of ferrite could also eliminate an industry wide reliance on Neodymium Iron Boron (NdFeB), the scarce and expensive rare-earth magnet used in existing designs. Another advantage of a ferrite-based design is that it’s less sensitive to the cooling problems that currently face existing DD-PMGs. This paper describes the development and testing of two prototype machines at nominal 2 kW and 70 kW power ratings. Moreover, the finite element analysis (FEA) and analytical steps employed to develop optimized designs together with the experimental verification are presented. The simulated and experimental results show good agreement which provides confidence in the design and modelling work completed

The role of BoFLC2 in cauliflower (Brassica oleracea var. botrytis L.) reproductive development

In agricultural species that are sexually propagated or whose marketable organ is a reproductive structure, management of the flowering process is critical. Inflorescence development in cauliflower is particularly complex, presenting unique challenges for those seeking to predict and manage flowering time. In this study, an integrated physiological and molecular approach was used to clarify the environmental control of cauliflower reproductive development at the molecular level. A functional allele of BoFLC2 was identified for the first time in an annual brassica, along with an allele disrupted by a frameshift mutation (boflc2). In a segregating F2 population derived from a cross between late-flowering (BoFLC2) and early-flowering (boflc2) lines, this gene behaved in a dosage-dependent manner and accounted for up to 65% of flowering time variation. Transcription of BoFLC genes was reduced by vernalization, with the floral integrator BoFT responding inversely. Overall expression of BoFT was significantly higher in early-flowering boflc2 lines, supporting the idea that BoFLC2 plays a key role in maintaining the vegetative state. A homologue of Arabidopsis VIN3 was isolated for the first time in a brassica crop species and was up-regulated by two days of vernalization, in contrast to findings in Arabidopsis where prolonged exposure to cold was required to elicit up-regulation. The correlations observed between gene expression and flowering time in controlled-environment experiments were validated with gene expression analyses of cauliflowers grown outdoors under 'natural' vernalizing conditions, indicating potential for transcript levels of flowering genes to form the basis of predictive assays for curd initiation and flowering time